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Genetics and Genomics

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SOS Repair of DNA in Prokaryotes

GENES-L4W7PE

The SOS response is a global response to DNA damage in which the cell cycle is arrested and DNA repair and mutagenesis are induced. The SOS repair system in bacteria is normally controlled by LexA repressor proteins.

Under normal conditions, LexA represses expression of the SOS genes. After DNA damage occurs, single-stranded (ssDNA) regions accumulate at replication forks, blocking DNA polymerase.

RecA binds to these ssDNA regions and becomes activated, after which it binds to and induces expression of the LexA repressor, lowering LexA protein concentrations and allowing expression of the SOS genes to repair the DNA damage.

SOS Repair after DNA is Damaged Hsiao, YT. "Open-i - Open Access Biomedical Image Search Engine | Open-i." Open-i - Open Access Biomedical Image Search Engine | Open-i. N.p., n.d. Web. 09 Apr. 2016. https://openi.nlm.nih.gov/detailedresult.php?img=PMC3348052_1471-2105-13-S7-S8-8&req=4a.

The

protein normally suppresses expression of the

protein.

When DNA damage occurs, these roles essentially reverse, thereby inducing the response. It is an error-prone repair system that can lead to mutagenesis.