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Genetics and Genomics

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Structure of Multiprotein Complexes

GENES-SG3HSR

Complexed proteins are linked by non-covalent protein–protein interactions. These complexes function to perform many biological processes inside the cell.

A multiprotein complex (or protein complex) is a group of two or more associated

chains. The different chains may have different functions. Multiprotein complexes are examples of the

level of protein organization. An example of a protein complex is the Bacillus amyloliquefaciens ribonuclease barnase and its inhibitor barstar, shown below.

The Bacillus amyloliquefaciens ribonuclease barnase (purple and yellow) and its inhibitor barstar (blue) in a complex. Regalis, Opabinia. Wikimedia Foundation, 5 Aug. 2006. Web. 17 Sept. 2016. https://commons.wikimedia.org/wiki/File:Barnase-barstar-1brs.png.