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Genetics and Genomics

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The Use of Haplotype in Human Genomic Analysis

GENES-1KTY2Y

In human genomics, haplotypes are regions of the genome that were inherited intact from an ancestral population - i.e. the sequence is identical to what would be found in the ancestor, at the base pair level.

Haplotypes can be identified by finding sets of single nucleotide polymorphisms (SNPs) that are in linkage disequilibrium such that they are always inherited together. The genomic region that contains these SNPs is the haplotype.

Which of the research goals below could be answered by analyzing an individual's haplotype?

Select ALL that apply.

A

Estimating when two human populations diverged from a common prehistoric ancestral population.

B

Identifying potential genetic causes of a disease which is unusually common in a certain human population.

C

Predicting which of two individuals is more likely to develop dementia.

D

Determining an individual's ancestry.