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When Jane refers to the "blasphemy against nature" in Chapter 17, she is speaking about
her dismay about not being born as beautiful as Blanche Ingram.
the injustice of cruel-minded women such as Blanche being born into wealth and affluence.
the fact that she and Rochester are equal in minds, but not in social status.
her dispair about growing up as an orphan.
the fact that Adèle is treated in a condescending manner by Rochester's guests simply because she is considered parentless.