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Neuroscience

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Cases of Synaptic Integration

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During synaptic integration, multiple post-synaptic potentials, EPSPs and IPSPs, are combined within one postsynaptic neuron, producing a summed membrane potential at the axon hillock. If that membrane potential exceeds the ​threshold, an action potential will fire.

Imagine we have a microelectrode that can record the axon hillock’s membrane potential, as well as three electrodes that can stimulate the activity of two excitatory synapses, E1, E2, and one inhibitory synapse, I1. It is known that simultaneous stimulation of E1 and E2 is just able to evoke an action potential.

Consider the following scenarios and fill in the blank possible consequence(s) for each synaptic integration, either "action potential" or "no action potential".

Note that for some scenarios there might be two correct answers.