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Common Neurotransmitter and Receptors


During the synaptic transmission at the chemical synapses, depolarization of the presynaptic terminal causes the opening of voltage-gated ${ Ca }^{ 2+ }$ channels and the influx of ${ Ca }^{ 2+ }$.

As a ${ Ca }^{ 2+ }$ influx causes presynaptic vesicles to fuse with the presynaptic membrane, neurotransmitters stored in the vesicles are released into the synaptic cleft. The binding of neurotransmitters to their receptors on the postsynaptic membrane causes opening or closing of postsynaptic channels, which lead to a ​change of membrane potential.

Based on what you know about the common neurotransmitters and their receptors, which of the following statements is FALSE?


Upon the binding of Acetylcholine, the permeability of postsynaptic neuron for ${ Na }^{ + }$ increases.


GABA is an inhibitory neurotransmitter.


Binding of glutamate to the ionotropic glutamate receptors has an excitatory effect on the postsynaptic neuron.


Upon the binding of dopamine, activated G-proteins regulate the intracellular concentration of cAMP to activate other ionic channels.