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Neuroscience

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Convergence in the Neurotransmitter Systems

NEURO-NAV@YP

Ionotropic glutamate AMPA receptors are expressed on the retinal ganglion cells and can be negatively regulated by cAMP-dependent protein kinase (PKA). Somatostatin is a neuropeptide transmitter, and its Gi-coupled receptors can be found in the retina.

Which of the following observations are consistent with somatostatin and glutamate neurotransmitter system convergence at the retinal ganglion cell synapse?

Select ALL that apply.

A

Pretreatment of retina with PKA activator abolishes effects of somatostatin on AMPA transmission.

B

Activation of the somatostatin receptors on the retinal ganglion cells suppresses AMPA currents.

C

Somatostatin receptors are expressed on the presynaptic terminals of bipolar cells where they modulate glutamate release.

D

Pretreatment of retina with pertussis toxin that inactivates Gi-coupled receptors abolishes effects of somatostatin on AMPA transmission.