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Differentiation of the Hindbrain: Role of Eph/ephrin

NEURO-A6@JP3

Eph receptors and their ligands ephrins are expressed at cell surface and may mediate cell adhesion, cell repulsion, as well as inhibit or promote cell migration. Specific Eph receptors and ephrins are expressed in only some, but not other segments (rhombomeres) of the developing hindbrain (rhombencephalon):

Stanislav Kholmanskikh. Created for Albert.io. Copyright 2016. All rights reserved.

Based on this expression pattern, what role Eph/ephrin interactions play in boundary formation in rhombencephalon?

A

Eph/ephrin interaction promotes cell migration between rhombomeres.

B

Eph/ephrin interaction mediates repulsion between cells from even numbered rhombomeres.

C

Eph/ephrin interaction mediates cell adhesion between cells within a rhombomere, but causes cell repulsion at the boundaries.

D

Eph/ephrin interaction halts all cell motility in the developing hindbrain.