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Neuroscience

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Differentiation of the Neural Tube: Mechanisms

NEURO-MTIBGI

Differentiation is a process of progressive restriction in the fates available to a cell from early to late stages of development. Neural tissue is first induced as a layer of neuroepithelium that later folds to form neural tube.

Which statement best describes the process of differentiation in the neural tube?

A

Every cell in the neuroepithelium follows an intrinsic program of differentiation specified at the time of neural tissue induction.

B

Cell fate specification in neuroepithelium along dosral-ventral and anterior-posterior axes is controlled by signaling centers found within and outside the developing neural tube.

C

Neuroepithelium cells themselves sort out neural tube regionalization and cell fate specification by exerting influence on their neighbors via direct cell-cell interactions.

D

Neural tube differentiation is initially a stochastic process that creates a rough map of future regions in the developing neural tube. Later in development rough patterning is refined via establishment of boundaries and cell migrations.