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Forebrain Differentiation: Plasticity of Neuronal Identity


Each area of the mature cerebral cortex is characterized by specific cytoarchitecture and pattern of connectivity. However, these attributes do not appear at once, but emerge gradually during forebrain differentiation.

Furthermore, prospective cortical neurons display a significant degree of plasticity in adopting various fates depending on their environment.

Taking into account these facts, which of the following correctly describes the development of the cerebral cortex?


Early in development, layer 5 neuron transplanted from the visual area into motor area will permanently retain its otherwise transient spinal axon.


Early in development, the entire cortical plate displays uniform cytoarchitecture even when all cortical neurons are already generated.


Layer 5 projection neurons make wide spread connections throughout the developing brain, including with areas that they are no longer connected to in the adult brain.


All of the above.