?

Neuroscience

Free Version

Upgrade subject to access all content

Difficult

Molecular Mechanism of Neurotransmitter Release

NEURO-YLVMBV

When it comes to the molecular mechanism of neurotransmitter release, scientists have come up with a model of vesicle fusion, starting with the step of vesicle docking.

Read the following descriptions about these steps, and select the CORRECT statement.

A

After the vesicle docks, SNARE proteins on the synaptic vesicle (synaptobrevin) and presynaptic membranes (syntaxin and SNAP-25) form a complex that pull the two membranes together.

B

Calcium ions enter through the adjacent calcium channels on the presynaptic membrane and bind to the synaptotagmin on the same membrane.

C

Calcium ions cause the synaptotagmin protein to insert into the synaptic vesicle membrane, binding to the SNARE complex and catalyzing membrane fusion.

D

Once the two membranes are fused together, neurotransmitters within the synaptic vesicle are released into the postsynaptic neuron.