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Neuroscience

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Neural Tube: Dorsal-Ventral Patterning

NEURO-7VRBX9

The neural tube is patterned along dorsal/ventral axis and anterior/posterior axis. The key players in the ventral patterning of neural tube are Sonic hedgehog (Shh) and retinoic acid (RA). They are secreted by the notochord and later by floor plate.

High Shh specifies motor neurons in the ventral neural tube and ventral interneurons. Wnt and bone morphogenic proteins (BMPs) on the other hand are secreted by the roof plate, and specify dorsal interneurons by antagonizing ventralizing activity of Shh.

Researchers found that Wnt signaling is also active in the ventral neural tube.

The evidence above would predict which of the following?

Select ALL that apply.

A

Experimental activation of Wnt signaling in the ventral neural tube alters neural fate from more ventral to more dorsal.

B

Experimental activation of Wnt signaling in the ventral neural tube represses expression of a Shh inhibitor Gli3.

C

Experimental ablation of Wnt signaling in the ventral neural tube promotes dorsal fate in ventral neural progenitors.

D

Experimental ablation of Wnt signaling in the ventral neural tube results in the expansion of cells with ventral fates.