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Neuroscience

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Neurogenesis: Inside-out Pattern of Corticogenesis

NEURO-3O$A99

A research method allows permanent labeling of all neurons born at the time of label injection. Using this method, it was established that during the development of the cerebral cortex, earliest born neurons end up in the deep layers, while later born neurons are found in the upper layers of the mature cortex.

Which of the following BEST explains this inside-out pattern of cortical development?

A

After reaching their appropriate position in the cortical plate, neurons divide again with their progeny moving further up.

B

After exiting the cell cycle, newly born neurons move all way up toward the pial surface and later born neurons form layers underneath them.

C

After exiting the cell cycle in the ventricular zone or subventricular zone, newly born neurons migrate up into the cortical plate, go past earlier born neurons. and settle down just above them.

D

Earlier born neurons are generated in the ventricular zone or subventricular zone and migrate up into the cortical plate, while later born neurons are generated in the molecular zone and migrate down.