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Neurogenesis: Zika Virus Caused Microcephaly

NEURO-BKU$ZP

The Zika virus may cause microcephaly in babies born to mothers infected with the virus during pregnancy. Microcephaly is an abnormally small brain. The virus causes a small brain at least in part by infecting neural progenitor cells and either killing them or inhibiting their proliferation.

Which of the following observations are consistent with this mechanism of Zika caused pathology?

Select ALL that apply.

A

Zika infection causes microcephaly when it happens during a period of active neurogenesis.

B

Cultured neural progenitor cells infected with Zika virus in vitro stop dividing.

C

Zika virus does not infect post-mitotic neurons.

D

Zika virus caused microcephaly was first reported in Brazil.