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Neuroscience

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NMDA Receptor: Coincidence Detector

NEURO-NG$LGK

NMDA (N-methyl-D-aspartate) receptors are glutamate receptor coupled ion channels permeable to positively charged ions; therefore their activation results in membrane depolarization. NMDA receptors are often referred to as coincidence detectors.

Why?

Stanislav Kholmanskikh. Created for Albert.io. Copyright 2016. All rights reserved.

A

NMDA receptors require action of agonists (glutamate) and co-agonists (glycine or D-serine) to be activated.

B

NMDA receptors are permeable to both calcium and sodium.

C

NMDA receptors are ligand- and voltage-gated.

D

NMDA receptors are important for learning and memory.