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Neuroscience

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Spatial Memory in Rats

NEURO-PULBBR

The Morris water maze is a standard test for spatial memory in rats. In this test, a rat is placed in a pool with cloudy water. Just below the water surface is a small hidden platform. The rat swims around until it finds and climbs onto this hidden platform, allowing an escape from the water.

Normally, with repeated trials, the rat learns the spatial location of the platform and swims straight to it.

Which of the following can result in enhanced learning (i.e. fewer trials needed) in the rat?

Samueljohn.de. Schematic drawing of the Morris water navigation task for rats (also known as Morris water maze). The animals should remember the position of the hidden (below surface) platform. Digital image. Wikipedia. N.p., 25 Nov. 2010. Web. 30 Apr. 2016.

A

Bilateral hippocampal lesion.

B

Injection of NMDA blockers into the hippocampus.

C

Overexpression of NMDA receptors in the hippocampus.

D

Placement of visual landmark over the platform.