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Neuroscience

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Wiring the Brain: Mechanisms of Cortical Plasticity

NEURO-YQWPTH

Monocular deprivation during the sensitive period for the development of the visual cortex results in the drastic reduction of innervation from the closed eye and matching expansion of inputs from the open eye. Concurrent application of Brain Derived Neurotrophic Factor (BDNF) blocks effects of monocular deprivation on the establishment of ocular dominance columns.

Which known activities of BDNF could account for this effect?

Select ALL that apply.

A

BDNF may stabilize axonal terminals and promote axonal branching.

B

BDNF may prevent cell death.

C

BDNF may potentiate efficacy at glutamatergic synapses.

D

BDNF released in its pro-BDNF form may induce cells death.