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What is the significance of the names of the towns "Weed" and "Soledad"?
The town names collectively represent the cycle of life because everyone dies alone.
Both town names represent George and Lennie's characters. George is lonely and, in the 1930s, intellectually disabled people like Lennie were considered useless like a weed.
Both town names are representative of life for vagrant workers during the 1930s, fruitless and lonely.
The two town names are a contrast, Weed representing death and Soledad representing life.
The two town names foreshadow what life will be like the ranch: lonely and deadly.