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# Azidothymine and HIV

ORGO2-2OEF23

Which one of the following statements BEST describes the action of AZT (azidothymine) on delaying the onset of symptoms and prolonging the lives of those infected with HIV?

A

AZT has a 5' $-OH$ group, so it can be incorporated into a growing polynucleotide chain. However, because it lacks a 3' $-OH$ group, the chain cannot be extended beyond it, and synthesis of the viral DNA stops before the chain is complete.​

B

AZT is similar to thymine, which makes it easier to incorporate into the virus DNA.

C

AZT kills the virus by stopping the growth of the cell wall of the virus​.

D

AZT is not very efficient for the treatment of the HIV​.

E

AZT inhibits the reverse transcriptase enzyme, which makes the synthesis of viral DNA difficult. Once the virus DNA synthesis is inhibited,​ it cannot attack the immune system of the host further.