Epoxides are an important functional group for organic synthesis. The principal reactions of epoxides involve ring-opening reactions with nucleophiles.
When epoxides react with a strong nucleophile such as a Grignard reagent or amine, the reaction
require the use of an acid catalyst. When a strong nucleophile reacts with an epoxide, it does so by attacking the
epoxide carbon. The nucleophile will attack from the
the epoxide oxygen.