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Organic Chemistry 2

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Epoxide Reactions in Organic Synthesis

ORGO2-BJRA@G

Epoxides are an important functional group for organic synthesis. The principal reactions of epoxides involve ring-opening reactions with nucleophiles.

When epoxides react with a strong nucleophile such as a Grignard reagent or amine, the reaction

require the use of an acid catalyst. When a strong nucleophile reacts with an epoxide, it does so by attacking the

epoxide carbon. The nucleophile will attack from the

the epoxide oxygen.