Organic Chemistry 2

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Preparation of Ethers, Mechanism 1


One of the principal ways to prepare ethers is the Williamson ether synthesis. In this reaction, an alkoxide ion is allowed to react with an alkyl halide (R-X) or alkyl tosylate (R-OTs). Select the appropriate answers from each dropdown to correctly complete these statements about the Williamson ether synthesis.

The Williamson ether synthesis is an

reaction. The alkoxide ion serves as the

. The alkyl halide or tosylate must be a

substrate for the reaction to be favored.