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Organic Chemistry 2

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Moderate

Robinson Annulation

ORGO2-RLOKQE

The Robinson annulation, which involves the coupling of an acidic carbonyl compound and an alpha, beta unsaturated ketone, is an excellent method to construct a six-membered ring and has often been used for the synthesis of steroidal compounds.

What is the product of the following reaction?

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A

Created for Albert.io. Copyright 2016. All rights reserved.

B

Created for Albert.io. Copyright 2016. All rights reserved.

C

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D

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E

Created for Albert.io. Copyright 2016. All rights reserved.