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A section of a sequence of coding mRNA reads "...AGG UUA CGC..."

Which of the following mutations would have the greatest effect on altering the shape of the protein and why?

A

A mutation that changed the first G to a C because it is a substitution.

B

A mutation that changed the last G to a C because it is a frameshift.

C

A mutation that eliminated the first G because it is a substitution.

D

A mutation that eliminated the first G because it is a frameshift.

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