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The electron transport chain (ETC), located in the inner membrane of the mitochondria, powers cellular respiration. As a final step in the process, cytochrome c oxidase transfers electrons to oxygen to form water.

Which of the following BEST predicts the outcome of an experiment where isolated mitochondria are treated with cyanide, an inhibitor of cytochrome c oxidase?


The electrons would reverse flow, moving toward the start of ETC.


Electron carriers would bypass cytochrome c oxidase and deliver electrons to a downstream acceptor.


Shutting down the ETC would not affect the Krebs cycle.


Electron carriers would remain reduced, cell damage and death would occur.

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