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Pompe's disease is a hereditary disorder caused by a DNA mutation in which the individual is unable to correctly synthesize functional lysosomal enzyme alpha-glucosidase (GAA), the enzyme that normally allows the cells to break down glycogen for energy.

How could a DNA mutation of this type produce the characteristics seen in those affected with this disorder?


The altered lysosomal enzymes catalyze the excessive breakdown of glycogen, causing the cells to run out of energy and die.


The mutated form of the DNA would produce an enzyme that would not be transported to the lysosomes. It would instead break down glycogen in the nucleus.


The mutated form of the enzyme cannot effectively break down glycogen. Therefore, glycogen is stored in the body instead of being broken down for energy.


The altered lysosomal enzymes break down proteins, instead of glycogen. The glycogen is stored in the body, destroying muscles and organs.

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