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Suppose a researcher wants to determine if a new weight loss drug is effective. She has $100\text{ volunteer subjects}$.

Which would be an appropriate method to determine the drug's effectiveness?

A

Have all $100$ of the subjects take the weight loss drug for three weeks and measure mean weight loss.

B

Give all $100\text{ subjects}$ the weight loss drug for three weeks, then no treatment for three weeks, and measure the differences in weight of the subjects both on the drug and off the drug.

C

Give half of the volunteers the new weight loss drug and the other half a placebo, then compare changes in weight between the two groups.

D

Draw subjects’ names out of a hat at random, giving the first $50$ the new weight loss drug and the remaining $50$ no treatment, then compare changes in weight between the two groups.

E

Draw subjects’ names out of a hat at random, giving the first $50$ the new weight loss drug and the remaining $50$ a placebo, then compare changes in weight between the two groups.

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