Limited access

Upgrade to access all content for this subject

Peptide primary structures are based on amide bonds.

Four scenarios of amide bond replacement are presented below, identify the altered properties or characteristics.

Scenario 1: Instead of an amide bond, an ester bond would
Select Option improve stabilityenhance hydrolysis rateenhance folding potentialreduce hydrolysis ratereduce solubility
of the primary structure. Scenario 2: Instead of an amide bond, a ketone bond would
Select Option improve stabilityenhance hydrolysis rateenhance folding potentialimprove hydrogen-bonding potentialenhance solubility
of the primary structure. Scenario 3: Instead of an amide bond, an imine bond would
Select Option improve hydrogen-bonding potentialreduce solubilityincrease the molecular weightenhance hydrophobic propertiesreduce stability
of the primary structure. Scenario 4: Instead of an amide bond, a thioester bond would
Select Option improve hydrogen-bonding potentialincrease the molecular weightimprove stabilityenhance folding potentialreduce folding potential
of the primary structure.
Select an assignment template