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Heparan sulfate (HS) is a polysaccharide that attaches to proteins in all animal tissues forming proteoglycans (HSPG).

Two or three HS chains will attach in close proximity to cell surface or extracellular matrix proteins where they can bind to ligands and regulate a variety of processes.

Which of the following statements about heparan sulfate is CORRECT?

J3D3 From work by Hsa2011. "Heparan Sulfate." Wikipedia. Wikimedia Foundation, 1 May 2016. Web. 02 May 2016.

A

Heparan sulfate is a highly-branched polysaccharide with a mass ranging from 3-10 kDa.

B

Heparan sulfate inhibits blood clotting by inhibiting the action of the protease inhibitor thrombin.

C

Heparan sulfate provides additional sites for viruses and bacteria to bind, facilitating their entry into the cell.

D

After attachment to proteins, heparan sulfate chains form amphipathic protrusions that allow them to interact with so many ligands.

E

Heparan sulfate binding to various cells regulate development and formation of blood vessels.

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