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When two compounds are called bioisosteres, it means that they are closely-related compounds with one single change that is NOT tied to the way the compounds are joined (that is actually what isomerism is). A change of halogen type, for example, is a great way to think of bioisosterism.

With respect to amino acids, which pair(s) of amino acids can be considered as bioisosteres?

Select ALL that apply.


Phenylalanine and tyrosine.


Serine and cysteine.


Aspartic acid and asparagine.


Leucine and isoleucine.

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