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​The cycle of replication of the E. coli chromosome requires a time of 60 minutes from the initiation of replication to the division of the cell. Despite this, the doubling time of E. coli can be as little as 18 minutes.



Cell division is not coordinated with DNA replication.


E. coli cells have multiple copies of the chromosome and only one completes replication with each cell division.​


Only a portion of the chromosome is replicated before each cell division.


The cell can initiate a new replication cycle before the previous replication cycle is finished.

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