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In order for a cancer cell to metastasize and leave the primary tumor, it has to become invasive and enter the circulation. Therefore the cell has to become less adhesive to neighboring cells and more migratory.

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For certain types of stomach and breast cancers, E-cadherin, a protein found associated with the cell junctional complex
Select Option adherens junctionsdesmosomesgap junctionstight junctions
, is found to be
Select Option increaseddecreased
in expression.
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