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Clathrin is a well-studied coat protein. It is particularly necessary for endocytosis of a variety of plasma membrane receptors in different cell types. Clathrin is well-known for its assembly into icosahedral cages that form around vesicles prior to and during intracellular transport.

How is clathrin recruited to assemble over specific receptors?


Clathrin binding to receptors happens constitutively with endocytosis occurring once receptors have clustered at specific endocytic zones.


Receptor activation results in recruitment of specific adaptor proteins that subsequently facilitate assembly of a clathrin-coated pit.


Receptors recruit clathrin through phosphorylation of the clathrin heavy chains after receptor activation.


Receptor activation induces changes in membrane composition, allowing clathrin recruitment and self-assembly.

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