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Surgery, radiation, and drugs are effective treatment strategies to treat cancers detected early. For advanced cancers, combination and sequential drug therapies have been developed as curative therapies.

Of the two strategies, why is combination drug therapy generally more therapeutic than sequential drug therapy? Select ALL that apply.

A

Single drug administration allows for the clonal expansion of drug resistant cells.

B

Cancer cells are hypermutable.

C

Most cancer cells in the tumor are resistant to a single drug.

D

Most cancer cells in the tumor are sensitive to multiple drugs.

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