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Changes in DNA methylation are recognized as major drivers of tumorigenesis.

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For example, 25% of acute myeloid leukemias arise from DNA hypomethylation in gene promoters. This is
Select Option an increasea decrease
in DNA methylation at
Select Option ApT islandsCpG islands
which leads to
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in gene expression. Conversely, a high proportion of colorectal cancers have DNA hypermethylation, which is
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in DNA methylation that generally leads to
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in gene expression.
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