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Many genomes cannot be completely sequenced even with the latest next-generation sequencing methods.

Which of the following choices represents the best reason for this?


Portions of some genomes have unusually high mutation rates and change so rapidly that they cannot be easily sequenced.


Many organisms have DNA that cannot easily be extracted from their tissues.


Repetitive DNA sequences are highly unstable and usually deteriorate before they can be sequenced.


Highly repetitive DNA sequences cannot be resolved with current mapping and sequence assembly algorithms.

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