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A mutation occurs in a protein-coding gene. The result of the mutation is that the gene is transcribed at the appropriate time, in the appropriate cells, and at the appropriate amount, but the resulting protein is missing of a ​stretch of amino acids in the middle of the sequence. The amino acid sequences before and after the missing section are intact.

Of the following, which mutation is most likely to have occurred?

A

A silent mutation.

B

A mutation in a 3' intron splice site.

C

A mutation in the gene's promoter.

D

A nonsynonymous point mutation.

E

A frameshift point mutation.

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