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Proteins destined for secretion must enter the endoplasmic reticulum.

This is called protein translocation.

Which of the following requirements must be met for protein translocation to occur?

Select ALL that apply.


Proteins must be appropriately targeted via an amino-terminal signal sequence or by a signal recognition particle.


Proteins MUST be completely synthesized before entering the endoplasmic reticulum.


Proteins must engage with the translocation pore in the endoplasmic membrane.


Completely synthesized proteins must have chaperones.


Proteins must be glycosylated before entering the endoplasmic reticulum.

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