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T helper cells require several signals to initiate proliferation and differentiation in an immune response.
Which of the following signals is NOT required for the full activation of T helper cells?
Binding of the T cell receptor (TCR) to the appropriate antigen, as presented by an MHC II molecule.
Interaction of CD28 with B7, displayed on the surface of an antigen presenting cell (APC).
Interaction of CTLA-4 with B7, displayed on the surface of an APC.
Binding of the cytokine IL-2 to its receptor on the surface of the T helper cell.