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Gap junctions allow the passage of small molecules, ions, and cytosol between connected cells. This allows cells to be coupled both via signaling cascades or electrically. Gap junctions, like other ionotropic channels, are not constitutively open.

What is one example of a physiological event that will cause the closing of gap junctions?

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Stimulation of cardiomyocytes by epinephrine.


Cardiomyocyte stimulation by acetylcholine.


Large increase in cytosolic calcium in hepatocytes.


Diffusion away from corresponding hemichannel in astrocytes.

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