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There are four major blood types found in humans based upon the presence or absence of the surface antigens A and B on red blood cells. These blood types are A, B, AB, and O. If the wrong blood is given to an individual, then an agglutination reaction occurs and the red blood cells would be destroyed.

Based on your knowledge of blood typing and the immune system, which of the following would explain why a person with type O blood could NOT receive blood from a type A donor?

A

A person with type O blood has no antigens; therefore, if type A blood is donated, the antigens on the surface of the A cells would attack the O blood and there would be an agglutination reaction.

B

A person with type A blood has A antigens and type O has no antigens; therefore, there would not be a reaction and type A could be donated.

C

A person with type A blood has anti-B antibodies; therefore, it would attack the antigens of type O blood and cause agglutination.

D

A person with type O blood has the anti-A and anti-B antibodies; therefore, if type A blood is given, the antigens on the surface of the cells would be attacked and there would be an agglutination reaction.

E

A person with type O blood does not have antibodies against any blood type antigens; therefore, it would not react with type A blood and it could be donated.

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