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Hormones are released into the interstitial fluid and then enter the bloodstream to be transported to target tissues throughout the body. There are two categories of hormones based on their solubility: the water-soluble hormones and the lipid-soluble hormones.

Which of the following describes how water-soluble hormones make changes within the target cells?


The hormone binds to cell-surface receptors on the target cell, initiating a signal transduction cascade inside the cell.


The hormone freely diffuses through the cell membrane and binds to intracellular receptors, most commonly affecting transcription.


The hormone is released into the interstitial fluid and affects only the surrounding cells.


The hormone is transported in vesicles and taken to the surface of the cell.

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