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The binding of a specific cyclin protein to a specific cyclin-dependent kinase (CDK) activates the CDK, which then phosphorylates other cellular proteins, as shown below. The activation of these cellular proteins then allows for the progression of the cell through a specific cell cycle checkpoint. While CDK levels are typically relatively constant, cyclin levels fluctuate over the course of the cell cycle.

Cyclin-CDK Complex. Digital image. Wikimedia Commons. Wikimedia Foundation, Inc., 4 Mar. 2007. Web. 16 Dec. 2016.

Suppose the gene encoding a specific cyclin was mutated so that the cyclin was no longer able to bind to its CDK. What effect would this have on the cell cycle?

A

There would be an uncontrolled progression through the cell cycle, leading to the development of cancer.

B

There would likely be no effect on the cell cycle.

C

Cells would be unable to progress through the cell cycle checkpoint and not continue through the cell cycle.

D

Cells would undergo mitosis prior to correct completion of DNA replication, introducing mutations.

E

Oncogenes would be transformed into proto-oncogenes.

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