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The binding of a specific cyclin protein to a specific cyclin-dependent kinase (CDK) activates the CDK, which then phosphorylates other cellular proteins, as shown below. The activation of these cellular proteins then allows for the progression of the cell through a specific cell cycle checkpoint. While CDK levels are typically relatively constant, cyclin levels fluctuate over the course of the cell cycle.

Cyclin-CDK Complex. Digital image. Wikimedia Commons. Wikimedia Foundation, Inc., 4 Mar. 2007. Web. 16 Dec. 2016.

Suppose the gene encoding a specific cyclin was mutated so that the cyclin was no longer able to bind to its CDK. What effect would this have on the cell cycle?


There would be an uncontrolled progression through the cell cycle, leading to the development of cancer.


There would likely be no effect on the cell cycle.


Cells would be unable to progress through the cell cycle checkpoint and not continue through the cell cycle.


Cells would undergo mitosis prior to correct completion of DNA replication, introducing mutations.


Oncogenes would be transformed into proto-oncogenes.

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