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Read the paragraph below on the pathway for the synthesis of insulin and fill in the blanks.

Insulin is created inside pancreatic cells and then secreted extracellularly for distribution throughout the body. Inside pancreatic cells, insulin synthesis starts at the
Select Option Golgi apparatuscisrough endoplasmic reticulumplasma membranesecretory vesicletrans
where the membrane-bound ribosomes translate messenger RNA into polypeptide chains that enter the secretory pathway. Secretory vesicles package insulin and are transported to the
Select Option Golgi apparatuscisrough endoplasmic reticulumplasma membranesecretory vesicletrans
. This second organelle then fuses with a third organelle called the
Select Option Golgi apparatuscisrough endoplasmic reticulumplasma membranesecretory vesicletrans
at the first receiving layer called the
Select Option Golgi apparatuscisrough endoplasmic reticulumplasma membranesecretory vesicletrans
face, and the polypeptides in these vesicles are modified inside the lumen of the third organelle. As the polypeptide reaches the end of the first layer, it buds out and fuses to another layer of the third organelle and repeats moving through the layers until it reaches the last layer and shipping face of the third organelle called the
Select Option Golgi apparatuscisrough endoplasmic reticulumplasma membranesecretory vesicletrans
face. From this shipping face, another second organelle buds out containing the finished insulin product. This second organelle fuses with the
Select Option Golgi apparatuscisrough endoplasmic reticulumplasma membranesecretory vesicletrans
so insulin is released outside the cell.
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