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The Krebs cycle is amphibolic (both anabolic and catabolic). This means it can be used to both build molecules (anabolic) and take them apart (catabolic). In order to be amphibolic, the entire cycle is more complex than it needs to be than if it was just used to break down acetyl-CoA. This complexity allows for specific intermediate molecules to be made that can be used to make fatty acids for energy storage, glucose for energy production, hemes to hold metals, certain amino acids for protein production, and even purines for nucleotide synthesis. Anabolism is the building up of molecules.

Citric Acid Cycle with Aconitate 2. Digital image. Wikimedia Commons, 12 Mar. 2009. Web. 20 Sept. 2016.

Using clues linking energy production and molecule breakdown in the Krebs cycle, one would expect anabolism to have what general relationship with energy?


Anabolism has no effect on energy.


Anabolism releases energy.


Anabolism requires energy input.

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