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An important part of gene regulation is the state of chromatin in regards to accessibility. By making the chromatin more open, the DNA can be more easily bound by transcription factors, and transcription will rise to higher levels. Conversely, by making chromatin more compact, transcription will be decreased.

For each of the following situations, determine whether the DNA would likely have a higher transcription or lower.

If a particular modification could lead to either higher or lower transcription depending on the exact circumstances, then leave the row blank.

Higher

Lower

The DNA is near the centromere.

The DNA is methylated.

The histones are acetylated.

The histones are methylated.

The DNA is near a telomere.

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