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In the race to determine the macromolecule responsible for heredity, Alfred Hershey and Martha Chase performed a series of experiments in 1952 using the T2 bacteriophage, a virus that specifically infects the bacterium Escherichia coli. They radioactively labeled components of the bacteriophage, allowed the bacteriophage to infect the bacteria, and then separated the bacteriophage from the bacteria to see what type of macromolecule had entered the bacterial cells. In one set of experiments, Hershey and Chase specifically labeled the proteins of the bacteriophage, while in another set of experiments, they specifically labeled the DNA.

Which of the following BEST describes the use of radioisotopes in their experimental design?

A

They used radioactive carbon to label the proteins and radioactive hydrogen to label the DNA.

B

They used radioactive nitrogen to label the proteins and radioactive oxygen to label the DNA.

C

They used radioactive iron to label the proteins and radioactive sulfur to label the DNA.

D

They used radioactive sulfur to label the proteins and radioactive phosphorus to label the DNA.

E

They used radioactive hydrogen to label the proteins and radioactive nitrogen to label the DNA.

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