B and T lymphocytes are white blood cells central to the function of the adaptive or acquired immune response. These cells undergo development in the bone marrow, leading to the production of lymphocytes with differing B and T cell receptors. These receptors recognize antigen that is complementary to the shape of the receptor.
In this process, the first step is the removal of unused D and J gene segments, allowing a specific D and J segment to come together. This step is followed by the recombination of the DJ gene segment with the selected V segment. The end product is a messenger RNA transcript encoding the receptor for either B or T cells.
This process of removal of unwanted gene segments and joining of specific D, J, and V sequences is known as