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Consider the following scenario. A loss of function mutation in the ligase gene results in the absence of the ligase protein.
During DNA replication on the lagging strand of a eukaryotic chromosome, which of the following outcomes is MOST likely?
DNA cannot be unwound at the replication fork.
The addition of new nucleotide bases is halted.
Additional RNA primers cannot be synthesized.
Phosphodiester bonds between Okazaki fragments are not produced.
RNA primers cannot be excised and replaced with DNA.