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Which TWO of the following chromosome variations would be the most deleterious in the early development of a multicellular organism?

A

Tandem duplication of part of one chromosome's arm.

B

Reciprocal translocation between two chromosomes.

C

Doubling the entire chromosomal content (genome duplication).

D

Halving the entire chromosomal content (2n to n).

E

An aneuploid trisomy.

F

An aneuploid monosomy.

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