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BLAST or Basic Local Alignment Search Tool is a widely used bioinformatics programs for specific sequence searching. It uses a heuristic (problem-solving) algorithm that is much faster than other approaches, allowing it to find matches much more rapidly.

Because genome databases contain so much information, BLAST is more practical as a starting algorithm, although subsequent algorithms can be even faster.

The first step of a BLAST is to remove any


highly specific regions in the query sequence.


low-complexity region or sequence repeats in the query sequence.


high-scoring sequence alignments.


high-scoring segment pairs.

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